The Strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review
Bibliographic record
Abstract
Soil-transmitted helminths (STH) represent a significant public health problem. However, Strongyloides stercoralis is not yet integrated into the control strategy against STH, given limitations to accurately assess its burden. Considering that S. stercoralis shares biological and epidemiological characteristics with hookworms, we describe a new approach for an improved estimation of the burden of infections by S. stercoralis based on the prevalence and burden of hookworms and the relationship between these species. A systematic review of publications reporting prevalence rates for S. stercoralis and hookworms was carried out. The data was classified into two categories: 1) "Community", with surveys including all age groups, and 2) "SAC", with surveys limited to school-aged children. The relationship between S. stercoralis and hookworms was characterized in order to estimate the global burden of S. stercoralis infections. The study is registered in PROSPERO (CRD42019131127). Spearman correlation coefficient between S. stercoralis and hookworms was estimated and the global burden of S. stercoralis infections was estimated using a regression model. A total of 119 articles were included, and a significant positive correlation between the burden of S. stercoralis and hookworms was identified. Spearman's coefficient for Community surveys was 0.94 and for SAC surveys it was 0.63. Based on the linear model, the global burden of S. stercoralis infections was estimated at 386 million (95%CI 324-449 million) people, including 22 million (95%CI 20-24 million) SAC. The significant relationship between S. stercoralis and hookworms allows an estimation of the global burden of S. stercoralis infections in most epidemiologic settings using hookworm burden and justifies the search of integrated control activities.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".