Targeting potential drivers of COVID-19: Neutrophil extracellular traps
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Abstract
Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.
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The record
- Venue
- The Journal of Experimental Medicine
- Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Field
- Immunology and Microbiology
- Canadian institutions
- McGill University Health Centre
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Allergy and Infectious DiseasesNational Heart, Lung, and Blood InstituteNational Institute of Diabetes and Digestive and Kidney DiseasesNational Cancer Institute
- Keywords
- ARDSNeutrophil extracellular trapsCytokine stormCoronavirus disease 2019 (COVID-19)AutopsyDiffuse alveolar damageImmunologyCytokineLungCoronavirusMedicineDiseaseInflammationInfectious disease (medical specialty)Acute respiratory distressPathologyInternal medicine
- Has abstract in OpenAlex
- yes