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Record W3020087243 · doi:10.1016/j.jcf.2020.04.012

A multinational report to characterise SARS-CoV-2 infection in people with cystic fibrosis

2020· article· en· W3020087243 on OpenAlexaff
Rebecca Cosgriff, Susannah Ahern, Scott C. Bell, K. Brownlee, Pierre‐Régis Burgel, Harriet Corvol, Stephanie Y. Cheng, Alexander Elbert, Albert Faro, Christopher H. Goss, Vincent Gulmans, Bruce C. Marshall, Edward F. McKone, Peter G. Middleton, Rasa Ruseckaite, Anne L. Stephenson, S.B. Carr, David W. Reid, Peter Wark, Géraldine Daneau, V. Boussaud, Graziella Brinchault, Emmanuelle Coirier-Duet, J.‐C. Dubus, Dominique Grenet, Sandra de Miranda, L. Beaumont, Reem Kanaan, Muriel Lauraens, Clémence Martin, Marie Mittaine, Anne Prévötat, Martine Reynaud‐Gaubert, Isabelle Sermet‐Gaudelus, Aurélie Tatopoulos, Lutz Nährlich, Barry J. Plant, Cedric Gunaratnam, Abaigeal Jackson, Karin M. de Winter-de Groot, Bart Luijk, Geertjan Wesseling, Mark I. Allenby, J. Duckers, Andrew Jones, R.I. Ketchell, Susan Madge, Anirban Maitra, Ghulam Mujtaba, Helen Rodgers, Nadia Shafi, Nicholas J. Simmonds, Kevin W Southern, Danie Watson, Samar Rizvi, J Seguin, J. Garbarz, Kristen Rosamilia, Maria Berdella, Jerry A. Nick, R. Belkin, Diana Gilmore, Kim McBennett, Rita Padoan, Marco Salvatore

Bibliographic record

VenueJournal of Cystic Fibrosis · 2020
Typearticle
Languageen
FieldMedicine
TopicCystic Fibrosis Research Advances
Canadian institutionsSt. Michael's HospitalCystic Fibrosis Canada
Fundersnot available
KeywordsCystic fibrosisMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakMultinational corporationVirologyPandemicBetacoronavirusPathologyInternal medicineInfectious disease (medical specialty)DiseaseOutbreak

Abstract

fetched live from OpenAlex

Information is lacking on the clinical impact of the novel coronavirus, SARS-CoV-2, on people with cystic fibrosis (CF). Our aim was to characterise SARS-CoV-2 infection in people with cystic fibrosis. METHODS: Anonymised data submitted by each participating country to their National CF Registry was reported using a standardised template, then collated and summarised. RESULTS: 40 cases have been reported across 8 countries. Of the 40 cases, 31 (78%) were symptomatic for SARS-CoV-2 at presentation, with 24 (60%) having a fever. 70% have recovered, 30% remain unresolved at time of reporting, and no deaths have been submitted. CONCLUSIONS: This early report shows good recovery from SARS-CoV-2 in this heterogeneous CF cohort. The disease course does not seem to differ from the general population, but the current numbers are too small to draw firm conclusions and people with CF should continue to strictly follow public health advice to protect themselves from infection.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score0.031

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0060.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0020.003
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.314
Teacher spread0.294 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations141
Published2020
Admission routes1
Has abstractyes

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