Influence of spatially segregated IP <sub>3</sub> -producing pathways on spike generation and transmitter release in Purkinje cell axons
Bibliographic record
Abstract
Significance IP 3 receptors are well-documented regulators of intracellular calcium concentration, but their role in axons of central neurons remains unexplored. Here we show that IP 3 receptors are present throughout the axon of cerebellar Purkinje cells where their activation leads to calcium release from intracellular stores. We reveal distinct, sharply delimited signaling cascades leading to IP 3 production in the axon initial segment (AIS), in the more distal part of the axon, and in synaptic terminals. In the AIS, IP 3 -induced calcium rises inhibit action potential generation, whereas similar signals in axonal terminals increase transmitter release. Metabotropic purinergic receptors appear to control the IP 3 -driven cascade. Altogether, the results reveal potent actions of IP 3 in central axons, which are both diverse and spatially constrained.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".