MétaCan
Menu
Back to cohort
Record W3021982075 · doi:10.1016/j.stem.2020.04.016

ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress

2020· article· en· W3021982075 on OpenAlexaff
Diana Guallar, Alejandro Fuentes-Iglesias, Yara Souto, Cristina Ameneiro, Óscar Freire-Agulleiro, José Ángel Pardavila, Adriana Escudero, Vera Garcia‐Outeiral, Tiago Moreira, Carmen Sáenz, Heng Xiong, Dongbing Liu, Shi-Di Xiao, Yong Hou, Kui Wu, Daniel Torrecilla, Jochen C. Hartner, Miguel G. Blanco, Leo J. Lee, Miguel López, Carl R. Walkley, Jianlong Wang, Miguel Fidalgo

Bibliographic record

VenueCell stem cell · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRNA regulation and disease
Canadian institutionsUniversity of Toronto
FundersAgencia Estatal de InvestigaciónEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentEuropean Regional Development FundInstituto de Salud Carlos IIINational Health and Medical Research CouncilAustralian Research CouncilNational Institute of General Medical SciencesFundación Ramón ArecesHealth Medical Collaborative Innovation Program of GuangzhouXunta de GaliciaCentre of Excellence for Electromaterials Science, Australian Research CouncilNational Institutes of HealthConsellería de Cultura, Educación e Ordenación Universitaria, Xunta de GaliciaMinisterio de Asuntos Económicos y Transformación Digital, Gobierno de EspañaVictorian Cancer AgencyMinisterio de Economía y CompetitividadMinisterio de Ciencia, Innovación y UniversidadesSecretaria Xeral de Investigación e Desenvolvemento, Xunta de GaliciaNew York State Department of Health
KeywordsReprogrammingBiologyCell biologyRNA editingInduced pluripotent stem cellTranscriptomeRNARNA-binding proteinEndoplasmic reticulumRNA silencingCell fate determinationSomatic cellCellGeneticsRNA interferenceGene expressionGeneTranscription factorEmbryonic stem cell

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.018
Threshold uncertainty score0.628

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.214
Teacher spread0.204 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations39
Published2020
Admission routes1
Has abstractno

Explore more

Same venueCell stem cellSame topicRNA regulation and diseaseFrench-language works237,207