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Record W3022270012 · doi:10.5206/mase/10221

Analysis of solutions and disease progressions for a within-host Tuberculosis model

2020· article· en· W3022270012 on OpenAlexafffundvenue
Wenjing Zhang, Federico Frascoli, Jane M. Heffernan

Bibliographic record

VenueMathematics in Applied Sciences and Engineering · 2020
Typearticle
Languageen
FieldMedicine
TopicMathematical and Theoretical Epidemiology and Ecology Models
Canadian institutionsYork University
FundersNatural Sciences and Engineering Research Council of CanadaTexas Tech University
KeywordsTuberculosisDiseaseLatency (audio)Host (biology)Mycobacterium tuberculosisBifurcationPathogenInfectious disease (medical specialty)BiologyImmunologyMedicineComputer sciencePathologyEcologyPhysics

Abstract

fetched live from OpenAlex

Mycobacterium tuberculosis infection can lead to different disease outcomes, we analyze awith-in host tuberculosis infection model considering interactions between macrophages, T lym-phocytes, and tuberculosis bacteria to understand the dynamics of disease progression. Fourcoexisting equilibria that reflect TB disease dynamics are present: clearance, latency, and pri-mary disease, with low and high pathogen loads. We also derive the conditions for backwardand forward bifurcations and for global stable disease free equilibrium, which affect how thedisease progresses. Numerical bifurcation analysis and simulations elucidate the dynamics offast and slow disease progression.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.005
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.002
Research integrity0.0030.002
Insufficient payload (model declined to judge)0.0060.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.055
GPT teacher head0.297
Teacher spread0.243 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2020
Admission routes3
Has abstractyes

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