A radiomics approach to artificial intelligence in echocardiography: Predicting post-operative right ventricular failure
Bibliographic record
Abstract
Abstract In this study, we describe a novel ‘radiomics’ approach to an echocardiography artificial intelligence system that enables the extraction of hundreds of thousands of motion parameters per echocardiography video. We apply this AI system to the clinical problem of predicting post-operative right ventricular failure (RV failure) in heart failure patients receiving implantable circulatory life support systems. Post-operative RV failure is the single largest contributor to short-term mortality in patients with left ventricular assist devices (LVAD); yet predicting which patient is at risk of developing this complication in the pre-operative setting, has remained beyond the abilities of experts in the field. We report results on testing datasets using a standard 10-fold cross validation. The AUC for the AI system trained using the Stanford LVAD dataset was 0.860 (95% CI 0.815-0.905; n = 290 patients) using pre-operative echocardiograms alone. We further show that our system outperforms board certified clinicians equipped with both contemporary risk scores (AUC 0.502 - 0.584) and independently measured echocardiographic metrics (0.519 – 0.598).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".