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Record W3023267018 · doi:10.1101/2020.04.23.20077412

A Novel Transfer Learning Model for Predictive Analytics using Incomplete Multimodality Data

2020· preprint· en· W3023267018 on OpenAlexfundno aff
Xiaonan Liu, Kewei Chen, Teresa Wu, David Weidman, Fleming Lure, Jing Li

Bibliographic record

VenuemedRxiv · 2020
Typepreprint
Languageen
FieldMathematics
TopicStatistical Methods and Inference
Canadian institutionsnot available
FundersNational Institutes of HealthGenentechIXICOH. Lundbeck A/SServierEisaiNorthern California Institute for Research and EducationPfizerBiogenBioClinicaF. Hoffmann-La RocheUniversity of Southern CaliforniaNovartis Pharmaceuticals CorporationU.S. Department of DefenseEli Lilly and CompanyBristol-Myers SquibbFoundation for the National Institutes of HealthAlzheimer's Disease Neuroimaging InitiativeMeso Scale DiagnosticsNational Institute on AgingAlzheimer's AssociationNational Institute of Biomedical Imaging and BioengineeringCanadian Institutes of Health ResearchNational Science Foundation
KeywordsMultimodalityComputer sciencePredictive analyticsTransfer of learningMachine learningArtificial intelligenceAnalyticsModalitiesMaximizationData mining

Abstract

fetched live from OpenAlex

Abstract Multimodality datasets are becoming increasingly common in various domains to provide complementary information for predictive analytics. In health care, diagnostic imaging of different kinds contains complementary information about an organ of interest, which allows for building a predictive model to accurately detect a certain disease. In manufacturing, multi-sensory datasets contain complementary information about the process and product, allowing for more accurate quality assessment. One significant challenge in fusing multimodality data for predictive analytics is that the multiple modalities are not universally available for all samples due to cost and accessibility constraints. This results in a unique data structure called Incomplete Multimodality Dataset (IMD) for which existing statistical models fall short. We propose a novel Incomplete-Multimodality Transfer Learning (IMTL) model that builds a predictive model for each sub-cohort of samples with the same missing modality pattern, and meanwhile couples the model estimation processes for different sub-cohorts to allow for transfer learning. We develop an Expectation-Maximization (EM) algorithm to estimate the parameters of IMTL and further extend it to a collaborative learning paradigm that is specifically valuable for patient privacy preservation in health care applications of the IMTL. We prove two advantageous properties of IMTL: the ability for out-of-sample prediction and a theoretical guarantee for a larger Fisher information compared with models without transfer learning. IMTL is applied to diagnosis and prognosis of the Alzheimer’s Disease (AD) at an early stage of the disease called Mild Cognitive Impairment (MCI) using incomplete multimodality imaging data. IMTL achieves higher accuracy than competing methods without transfer learning.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.009
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.276
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.009
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.567
GPT teacher head0.462
Teacher spread0.105 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designSimulation or modeling
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2020
Admission routes1
Has abstractyes

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