Targeting Rho to Stimulate Repair After Spinal Cord Injury
Bibliographic record
Abstract
Growth inhibitory proteins block axon regeneration in the CNS. Many growth inhibitory proteins have been identified, and the Nogo66 receptor (NgR) binds the three major myelin-derived inhibitors. Many studies now indicate that NgR signals to the small GTPase Rho. Our studies have shown that Rho is an important intracellular target for overcoming growth inhibition and promoting axon regeneration after injury. The inactivation of the Rho signaling pathway promotes neurite outgrowth of primary neuronal cell cultures plated on growth inhibitory substrates. To inactivate Rho signaling, C3 transferase, C3-05 (Cethrin; a more potent C3 transferase derivative), and Y-27632, an inhibitor of Rho kinase, have been tested. In vivo, we have documented the regeneration of transected axons after treatment with C3 transferase, C3-05, and Y-27632. C3 transferase and C3-05 have been tested in two animal models: microcrush lesion of the adult rat optic nerve and over-hemisection of adult mouse spinal cord. Treatment with C...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".