MétaCan
Menu
Back to cohort
Record W3025007192 · doi:10.1016/j.jcv.2020.104433

Real-time PCR-based SARS-CoV-2 detection in Canadian laboratories

2020· article· en· W3025007192 on OpenAlexafffundabout
Jason J. LeBlanc, Jonathan B. Gubbay, Yan Li, Robert Needle, Sandra Radons Arneson, D Marcino, Hugues Charest, Guillaume Desnoyers, Kerry Dust, Ramzi Fattouh, Richard Garceau, Gregory German, Todd F. Hatchette, Robert Kozak, Mel Krajden, Theodore I. Kuschak, Amanda Lang, Paul N. Levett, Tony Mazzulli, Ryan McDonald, Samira Mubareka, Natalie Prystajecky, Candy Rutherford, Marek Smieja, Yang Yu, George Zahariadis, Nathan Zelyas, Nathalie Bastien

Bibliographic record

VenueJournal of Clinical Virology · 2020
Typearticle
Languageen
FieldMedicine
TopicSARS-CoV-2 detection and testing
Canadian institutionsMount Sinai HospitalSunnybrook HospitalBC Centre for Disease ControlSunnybrook Health Science CentreSt. Michael's HospitalSaskatchewan HealthDr. Georges-L.-Dumont University Hospital CentreSt. Joseph’s Healthcare HamiltonInstitut National de Santé Publique du QuébecUniversity of TorontoSt. John’s Health Sciences CentreSte. Anne's HospitalDalhousie UniversityPublic Health Agency of CanadaSaskatchewan Health AuthorityNova Scotia Health AuthorityToronto Public HealthPublic Health OntarioHospital for Sick Children
FundersNationale Genossenschaft für die Lagerung radioaktiver AbfälleUniversity of Saskatchewan
KeywordsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakPandemicVirologyMedicineInfectious disease (medical specialty)OutbreakPathology

Abstract

fetched live from OpenAlex

With emergence of pandemic COVID-19, rapid and accurate diagnostic testing is essential. This study compared laboratory-developed tests (LDTs) used for the detection of SARS-CoV-2 in Canadian hospital and public health laboratories, and some commercially available real-time RT-PCR assays. Overall, analytical sensitivities were equivalent between LDTs and most commercially available methods.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.157
Threshold uncertainty score0.315

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0060.010
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.001
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.097
GPT teacher head0.397
Teacher spread0.300 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations149
Published2020
Admission routes3
Has abstractyes

Explore more

Same venueJournal of Clinical VirologySame topicSARS-CoV-2 detection and testingFrench-language works237,207