Clinical application ofthe photopic negative response to the flash electroretinogram in open angle glaucoma
Bibliographic record
Abstract
目的 评价视网膜电图(electroretinogram,ERG)的明视负波反应(phtopic negativeresponse,PhNR)在开角型青光眼患者中的临床应用价值.方法 应用美国ESPION视觉电生理仪及一次性使用的DTL微纤维电极测量67例(67眼)正常人(年龄为21～76岁)、41例(62眼)开角型青光眼患者(年龄为21～77岁)的PhNR.全视野刺激器由LED光源发光,选用蓝色背景光(亮度为10cd/m2),刺激光为红色光(刺激光强度分别为1 cd·s/m2、5 cd·s/m2和7cd·s/m2).采用Humphrey C30-2程序检查患者的视野,根据视野检查结果将青光眼患者分为早期组12例(21眼),进展期组13例(17眼)和晚期组16例(24眼).在记录视网膜电图时,患者的眼压控制在正常范围内.检查患者的眼底并测量视盘的杯盘比.结果正常人的明视ERG都有伴随b波的缓慢的负向电位,即PhNR,其振幅随年龄的增大而降低.青光眼患者的a波及b波的振幅和潜伏期与年龄匹配的正常值对照差异无显著性,但是PhNR振幅较正常值明显降低,甚至在视野敏感度轻度缺失的早期组患者就出现PhNR的振幅下降,并且随视野敏感度缺失的增加,进展期和晚期组患者PhNR的振幅下降更加明显.在全部青光眼患者中,PhNR的振幅与视野的平均偏差(meandeviation,MD)、模式标准差(pattern standard deviation,PSD)和垂直方向的杯盘比(C/D)存在明显的相关性(P＜0.01).结论开角型青光眼患者的PhNR的振幅比正常对照组低,PhNR振幅降低与青光眼病情的严重程度相关,早期青光眼患者的PhNR振幅就出现下降,并随视野敏感度缺失的增加下降更加明显.PhNR振幅降低对青光眼有较高的敏感性和特异性.PhNR可以作为开角型青光眼的早期检测及其青光眼损伤进展的一个视功能评价指标。
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".