Change of serum interleukin-23 levels and sacroiliac joint magnetic resonance imaging before and after treatment with recombinant human tumor necrosis factor-α receptor II IgG Fc fusion protein for injection in axial spondyloarthritis patients
Bibliographic record
Abstract
Objective We investigated interleukin (IL)-23 that might play a role in the pathogenesis of rheumatoid arthritis (RA) and whether it was correlated with disease activity and clinical manifestations in axial spondyloarthritis(SpA). In addition, the Spondyloarthritis Research Consortium of Canada (SPARCC) scores was used to examine whether recombinant human tumor necrosis factor-α receptor Ⅱ IgG Fc fusion protein for injection (rhTNFR: Fc) was effective for the reduction of magnetic resonance imaging (MRI)-proven sacroiliac joint (SIJ) inflammation. Methods The serum IL-23 levels of etanercept and conven-tional treatment groups were measured using enzyme-linked immunosorbent assay kits. At the same time, SIJ MRI SPARCC score levels were assessed by MRI, the change of clinical indicators of patients was observed. ANOVA, repeated measure data of ANOVA and Spearman's correlation analysis were used for statisical analysis. Results ① The basal serum IL-23 levels of the Etanercept group were (34.2±1.8) pg/ml and those of the conventional treatment group were (34.1±1.8) pg/ml (F=1 073.790, P=0.991) , both were significantly higher than the healthy control group (18.1±0.8) pg/ml (P=0.005). After treatment, serum IL-23 levels of the rhTNFR: Fc treatment and conventional treatment group were (24.5±1.7) pg/ml and (25.2±1.7) pg/ml (F=232.488, P=0.242) , (19.2±0.8) pg/ml and (21.6±1.3) pg/ml (F=114.135, P=0.025) , (19.0±0.8) pg/ml and (19.4±0.8) pg/ml (F=23.374, P=0.085) respectively. A significant decrease was observed in the two groups and the serum level of IL-23 of the rhTNFR: Fc group was lower than that of the conventional group at week 12. ② SIJ MRI SPARCC scores of the rhTNFR: Fc group and the conventional drugs group were (20.1± 1.2) scores and (20.7±1.5) scores (F=2003.660, P=0.191) , (12.5±0.8) scores and (15.4±0.9) scores (F=1 680.430, P=0.004) , (8.8±0.9) scores and (12.8± 0.9) scores (F=972.877, P=0.002) , the scores of two group were significantly decreased after treatment. At week 12, 24 of the treatment, the rhTNFR: Fc group scores were lower than the conventional drugs group. ③ The serum IL-23 levels, SIJ MRI SPARCC scores and clinical index (ESR, CRP, PGA, BASDAI, BASFI, BASMI and number of painful joints) were not correlated (P>0.05), the SIJ MRI SPARCC scores and clinical indicators were not correlated (P>0.05). Conclusion ① The serum IL-23 levels of the rhTNFR: Fc are higher than healthy controls. ② rhTNFR: Fc treatment could significantly decrease IL-23 levels and improve the sacroiliac joint inflammation compared to conventional treatment. ③ SIJ MRI is a good assessment method for the detection of SpA sacroiliac joint inflammation. Key words: Arthritis; Interleukins; Sacroiliac joints; Magnetic resonance imaging
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".