Relationship between serum cystatin C and cognitive impairment in patients with acute cerebral infarction
Bibliographic record
Abstract
Objective To explore the correlation between serum cystatin C (CysC) and cognitive function and executive function in patients with acute cerebral infarction. Methods A total of 103 patients with acute cerebral infarction were selected in clinical research. Based on the Montreal cognitive assessment scale (MoCA), patients were divided into cognitive impairment group and normal cognitive group. The levels of serum CysC and MoCA subtypes were compared between the two groups, and the correlation between cystatin C and cognitive function was analyzed. According to the level of serum CysC, the patients were divided into low-level group and middle-high level group. The relationship between CysC and executive function was further investigated by Stroop test. Results CysC was a risk factor of cognitive impairment in the acute phase after cerebral infarction (OR=8.855, 95%CI=1.674-46.841, P=0.010), and the level of CysC was negatively correlated with MoCA score (r=-0.509, P=0.001). In each of the MoCA subproject, the scores of the cognitive impairment group(clock drawing: 0(0, 1), connection: 0(0, 0), copying the cube: 0(0, 0)) were lower in clock drawing, connection, and copying the cube than that of the normal cognitive group(clock drawing: 3(2, 3), connection: 1(0, 1), copying the cube: 1(1, 1))(P<0.05). The difference of task C between low-level CysC group and middle-high level group was statistically significant(P<0.05). The level of CysC was negatively correlated with amount of interference in correct response(r=-0.471, P<0.05), and positively correlated with amount of interference in reacting time(r=0.796, P<0.05). Conclusion Serum CysC is a risk factor of cognitive impairment in acute cerebral infarction. The higher the level of CysC, the more serious cognitive impairment, and cognitive impairment mainly manifested as executive function impairment. Key words: Cerebral infarction; Cystatin C; Cognitive impairment; Executive function
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".