The Effect of L-T4 Replacement Therapy on Cognitive Status in Old Patients with Subclinical Hypothyroidism
Bibliographic record
Abstract
Objective To investigate the effect of L-T4 replacement therapy on cognitive status in old Patients with subclinical hypothyroidism(SCH).Methods 64 old patients with preliminarily diagnosed subclinical hypothyroidism newly were investigated with Montreal Cognitive Assessment(MoCA).and the concentrations of FT3,FT4 and TSH were measured.After L-T4 replacement therapy for 6 months,all the indices above were remeasured and compared.Results After thyroid hormone replacement therapy for 6 months,the patients with mild cognitive impairment increased from 20(41.7%)to11(22.9%)in all patients,and the scores on MoCA full score,memory,execution function,language and attention improved more obviously than that before replacement thempy.Conclusion The treatment of thyroid hormone on the old patients with SCH had positive effects,which could improve the cognition level especially in memory,execution function,language and attention. Key words: Subclinical hypothyroidism; Thyroid hormone; Montreal Cognitive Assessment; Cognition
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".