The characteristics of cognitive impairment in patients with primary hypothyroidism
Bibliographic record
Abstract
Objective To observe the characteristics of cognitive impairment in patients with primary hypothyroidism. Methods A total of 90 primary hypothyroidism patients untreated with thyroid hormone were selected.All the 90 patients were divided into subclinical hypothyroidism group, mild or moderate hypothyroidism group and serious hypothyroidism group, and 30 patients in each group.The other 30 healthy volunteers were selected as controls. Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used for the testing their orientation, immediate memory, attention and calculation, delayed recalling, linguistic competence, visual space and execution, naming ability and abstracting power. One-way analysis of variance was performed to determine significant differences among four groups. Results The MMSE scores in subclinical hypothyroidism group , mild or moderate hypothyroidism group and serious hypothyroidism group((27.53±2.16), (26.90±1.88)and (24.80±2.10)respectively) were lower than those of the control (28.23±1.33). The MoCA scores of the above hypothyroidism groups((23.57±3.33), (21.60±2.81) and (20.53±3.03)respectively) were also lower than that of the control (26.63±2.31)(P<0.05). Except for orientation and immediate memory, statistical significances of the other cognitive function were existed between hypothyroidism groups and the healthy controls (P<0.05). With the increase in severity of hypothyroidism, the abnormality of attention, calculation, linguistic competence, visual space and executive ability, naming ability and abstracting power were appearing gradually in hypothyroidism groups(P<0.05), and the scores were low(P<0.05). Conclusion Defects of attention and calculation, delayed recalling, linguistic competence, visual space and execution, naming ability and abstracting power are existed in primary hypothyroidism patients. Key words: Primary hypothyroidism; Cognitive impairment; Subclinical hypothyroidism
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".