Transplantation of human islets in 8 diabetic patients with Edmonton immunosuppressive protocol
Bibliographic record
Abstract
目的 探讨成人胰岛移植治疗1型糖尿病的临床效果.方法 为8例1型糖尿病患者施行胰岛移植,供胰来自于成人尸体,消化、分离获得的胰岛培养过夜,然后经动脉插管输注至肝固有动脉,每例输注胰岛数为(8415±757)胰岛当量/kg,其中3例接受1个供者的胰岛移植,5例接受2个供者的胰岛移植(分2次进行).8例患者中,除1例供、受者的ABO血型不同外,其余供、受者的ABO血型均相同.本组病例未行HLA配型.术后免疫抑制治疗采用Edmonton方案中的免疫抑制剂使用方法,即不使用类固醇激素,采用西罗莫司和他克莫司联用,并辅以5剂达利珠单抗.术后观察外源性胰岛素的使用量、血糖及血清C-肽的变化.结果 移植后平均随访7.7个月,2例完全停用胰岛素,5例的胰岛素用量减少47%～90%,1例效果不明显,胰岛素用量仅减少21%.8例血糖从移植前的(10.6±3.9)mmol/L降至(6.6±1.3)mmol/L,控制更为平稳;糖化血红蛋白A1从(11.9±1.6)%降至(5.9±1.2)%.移植有效者的血清C-肽基础值及葡萄糖刺激后C-肽水平分别由移植前的(0.054±0.076)nmol/L和(0.075±0.045)nmol/L升高至(0.620±0.080)nmol/L和(1.580±0.770)nmol/L.免疫抑制剂相关的并发症主要为白细胞减少(6例),减少或停用免疫抑制剂后白细胞可回升至正常,无大出血、门静脉栓塞或门静脉高压等并发症发生.结论 经肝动脉输注成人胰岛治疗1型糖尿病具有一定的临床效果,采用Edmonton免疫抑制方案安全、有效。
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".