Case Report of Refractory Psoriatic Arthritis Achieving Remission Using<i>Nigella sativa</i>(Black Seed Oil) Extract
Bibliographic record
Abstract
To the Editor: Psoriatic arthritis (PsA) is one of the major extra skin manifestations of psoriasis and will develop in 20–30% of patients with psoriasis1. Alternative medicines, mainly herbal products, have been commonly used by patients for the treatment of psoriasis and there have been some studies into their efficacy, but most cases of PsA still require systemic therapy2. Extract from Nigella sativa , also known as black seed oil, has been found to have antiproliferative, antiosteoporotic, antiinflammatory, and antidiabetic effects in many studies3. The major active ingredient, thymoquinone, has been demonstrated to have comparable results with topical hydrocortisone 2.5% when applied topically on carrageenan-induced paw edema and granuloma pouch on rats, manifested by a notable decrease in leukocyte count and tumor necrosis factor-α concentration in inflamed … Address correspondence to Dr. D.D. Gladman, Toronto Western Hospital, 399 Bathurst St. 1E-410B, Toronto, Ontario M5T 2S8, Canada. E-mail: dafna.gladman{at}utoronto.ca
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.010 | 0.005 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".