Scalable microfabrication of drug-loaded core–shell tablets from a single erodible polymer with adjustable release profiles
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Oral tablets with tunable release profiles have emerged to enhance the effectiveness of therapies in different clinical conditions. Although the concept of tablets with adjustable release profiles has been studied before, the lack of a fast and scalable production technique has limited their widespread application. In this study, a scalable fabrication method was developed to manufacture controlled-release polyanhydride tablets. A new polymeric core-shell tablet design is also proposed, that in conjunction with a micro-fabrication procedure, allows for achieving tunable release profiles required in personalized medicine in small-size tablets. Utilizing a surface-erodible polymeric carrier in the fabrication of the new tablet design resulted in achieving adjustable release profiles and improvements in the drug-loading capacity of the delivery system which allows for delivering a flexible amount of therapeutics with desirable patterns to patients. The proposed fabrication techniques allow for scalable production of personalized tablets with the high resolution required in precision medicine and hence have a high potential for clinical translation.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it