Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish
Why this work is in the frame
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Bibliographic record
Abstract
Significance The secretory granule protein secretogranin-2 is processed to the bioactive neuropeptide secretoneurin. While these are expressed in hypothalamic neurons and anterior pituitary cells, a role in hormonal control of reproduction is unknown. We provide in vivo evidence that secretogranin-2 plays critical roles in fertility regulation. Mutation of the secretogranin-2a and -2b genes in zebrafish leads to disrupted sexual behaviors, reduced ovulation and egg laying, and suboptimal fertility and embryo survival. Injection of a synthetic secretoneurin peptide enhanced reproductive outcomes in the mutant fish. Our secretogranin-2 mutants offer an amenable model system in which to screen potential injectable stimulators of reproduction, be they for spawning in cultured fish species, or to help with the search for new human infertility treatments.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it