Record W3033038732 · doi:10.1210/clinem/dgaa348

The Effect of Ethnicity in the Rate of Beta-Cell Functional Loss in the First 3 Years After Type 1 Diabetes Diagnosis

2020· article· en· W3033038732 on OpenAlexaff

Mustafa Tosur, Mario A. Cleves, Jay M. Sosenko, Ingrid Libman, David A. Baidal, Ashok Balasubramanyam, María J. Redondo, Carla J. Greenbaum, Mark S. Anderson, Peter A. Antinozzi, Mark A. Atkinson, M. Battaglia, Dorothy Becker, P. J. Bingley, Emanuele Bosi, Jan C. Buckner, Peter G. Colman, Linda A. DiMeglio, Stephen E. Gitelman, Robin Goland, Peter A. Gottlieb, Kevan C. Herold, Richard A. Insel, Tom Kay, Mikael Knip, Jeffrey P. Krischer, Åke Lernmark, Jennifer B. Marks, Antoinette Moran, Jerry P. Palmer, Mark Peakman, Louis H. Philipson, Alberto Pugliese, Philip Raskin, Henry Rodriguez, Bart O. Roep, W. J. Russell, Lisa M. Spain, Desmond Schatz, Diane K. Wherrett, Darrell M. Wilson, William E. Winter, Anette‐Gabriele Ziegler, Christophe Benoıst, Janice S. Blum, Katarzyna Bourcier, Peter Chase, Michael Clare‐Salzler, Raphael Clynes, George S. Eisenbarth, C. Garrison Fathman, Gilman D. Grave, Bernhard J. Hering, Francine Kaufman, Ellen Leschek, J. Mahon, Kirsti Näntö‐Salonen, Gerald T. Nepom, T Orban, Robertson Parkman, Mark D. Pescovitz, John Peyman, Maria Grazia Roncarolo, Peter J. Savage, Olli Simell, Robert Sherwin, Mark Siegelman, Jay S. Skyler, Andrea K. Steck, James W. Thomas, Massimo Trucco, J. Richard Wagner, Lisa Rafkin, Catherine C. Cowie, Mary A. Foulkes, Saúl Malozowski, J P Ridge, Stephanie J. Zafonte, Norma S. Kenyon, Irene Santiago, Brian N. Bundy, Michael Abbondondolo, Timothy E. Adams, Darlene Amado, Ilma Asif, Matthew Boonstra, Cristina Burroughs, David Cuthbertson, Mary Deemer, Christopher Eberhard, Steve Fiske, Julie Ford, Jennifer Garmeson, Heather Guillette, Susan Geyer, Courtney Henderson, Martha Henry, Kathleen Heyman, Belinda Hsiao, Christina Karges, Nichole Keaton, Amanda Kinderman, Pat Law, Ashely Leinbach, Cristin Linton, Shu Liu, Jennifer Lloyd, Jamie Malloy, Kristin Maddox, Julie Martin, Jessica Miller, Éric Milliot, Margaret Moore, Sarah Müller, Thuy Trang Nguyen, Ryan O’Donnell, Vanessa Oduah, Jennifer Pilger, Amy E. Roberts, Kelly Sadler, Tina Stavros, Roy Tamura, Keith Wood, Ping Xu, Kenneth C. Young, Persida Alies, Franz Badias, Aaron Baker, Monica Bassi, Craig A. Beam, David Boulware, London Bounmananh, Susan Bream, Doug Freeman, Jessica Gough, Jinin Ginem, Moriah Granger, Mary Holloway Michelle Kieffer, Page Lane, Lavanya Nallamshetty, Yazandra Parrimon, Joy Ramiro, AQesha Luvon Ritzie, Archana Sharma, Audrey C. Shor, Xiaohong Song, Amanda Terry, Jeanne Weinberger, Margaret Wootten, Pamela Harding, Susan McDonough, Kimberly Owens Hess, Donna Phoebus, Scott Quinlan, Erica Raiden, Emily Batts, Chris Buddy, Kristin Kirpatrick, Mary Ramey, Ann Shultz, Chris Webb, Melita Romesco, Judith Fradkin, Emily A. Blumberg, Gerald J. Beck, David J. Brillon, Rose Gubitosi‐Klug, Lori M. Laffel, Robert M. Veatch, Dennis Wallace, Jonathan Braun, Bernard C. Lo, Herman Mitchell, Ali Naji, Jørn Nerup, Trevor J. Orchard, Michael W. Steffes, Anastasios A. Tsiatis, Bernard Zinman, Brett Loechelt, Lindsey R. Baden, Michael D. Green, Adriana Weinberg, Santica M. Marcovina, Adriana Weinberg, Liping Yu, Sunanda Babu, David Gómez, Xiati Zheng, Sandra Lidia Peralta Peña, Massimo Pietropaolo, Tyler Brown, Jane H. Buckner, Angela Dove, Marissa Hammond, Deborah Hefty, Jani Klein, Kristen Kuhns, McKenzie Letlau, Sandra Lord, Marli McCulloch‐Olson, Lisa M. Miller, Jared Odegard, Elaine Sachter, Marissa St. Marie, Kimberly Stickney, Dana VanBuecken, Ben Vellek, Christine A. Webber, Laurie Allen, Jenna Bollyk, Nicole Hilderman, Hebatullah Ismail, Steve Lamola, Srinath Sanda, Heather Vendettuoli, David Tridgell, Roshanak Monzavi, Meredith Bock, Lynda K. Fisher, Mary Halvorson, Debra Jeandron, Mimi S. Kim, Jamie Wood, Mitchell E. Geffner, Christine Salazar, Steve Cook, Matthew Freeby, Mary Gallagher, Rachelle Gandica, Ellen Greenberg, Amy Kurland, Sarah Pollak, Amy Wolk, Mary Chan, Linda Koplimae, Elizabeth Levine, Kelly Smith, Jeniece Trast, Janice Blum, Carmella Evans‐Molina, Robin Hufferd, Bonnie Jagielo, Christy Kruse, Vanessa Patrick, Mark Rigby, Maria Spall, Kim Swinney, Jennifer Terrell, Lyla Christner, LeeAnn Ford, Sheryl Lynch, M D Stamm Menendez, Patricia Merrill, Cielo Alleyn, S.D. Fay, Jason L. Gaglia, Brittany Resnick, Sarah Szubowicz, Gordon C. Weir, Ronald Benjamin, Debbie Conboy, Andrea deManbey, Richard A. Jackson, Heyam Jalahej, Alyne Ricker, Joseph I. Wolfsdorf, Huihui Zhang, Tandy Aye, Bonita K. Baker, Karen Barahona, Bruce A. Buckingham, Kerry Esrey, Trudy Esrey, Garry Fathman, Radhika Snyder, Beenu Aneja, Maya Chatav, Oralia Espinoza, Eliana Frank, Jenny Liu, Jennifer Perry, Rebecca Pyle, Alison Rigby, Kristin Riley, Adriana Soto, Saleh Adi, M. S. Anderson, Ashley Berhel, Kathy Breen, Kathleen Fraser, Andrea Gerard‐Gonzalez, Paula Jossan, Robert H. Lustig, Sara Moassesfar, Amy Mugg, David C. Ng, Priya Prahalod, Martha Rangel‐Lugo, Joshua Tarkoff, Christine Torok, Rebecca Wesch, Ivy R. Aslan, Jeanne Buchanan, Jennifer Cordier, Celia Hamilton, Louise Hawkins, Thu Ho, Anjali Jain, Karen Ko, Theresa M. Lee, Shelly Phelps, Stephen M. Rosenthal, Taninee Sahakitrungruang, Lorraine Stehl, Lisa A. Taylor, Marcia Wertz, Jenise C. Wong, Rosemary Briars, Nancy Devine, Elizabeth Littlejohn, Tiffany Grant, Georgeanna J. Klingensmith, Aimon K. Alkanani, Kimberly Bautista, Ruth Bedoy, Aaron Blau, B. J. Burke, Laraine Cory, Mylinh Dang, Lisa Fitzgerald-Miller, Alex Fouts, Vicky Gage, Satish K. Garg, Patricia Gesauldo, Raymond Gutin, Cory J. Hayes, Michelle Hoffman, Kaitlin Ketchum, Nyla Logsden-Sackett, David M. Maahs, Laurel H. Messer, Lisa Meyers, Aaron W. Michels, Stesha Peacock, Marian Rewers, Perla Rodriguez, Flor Sepulbeda, Rachel Sippl, Iman Taki, Bao-Khan Tran, Tuan Tran, R. Paul Wadwa, Philip Zeitler, Jennifer M. Barker, Sandra Barry, Laurie Birks, Leah Bomsburger, Terra Bookert, Leah Briggs, Patricia Burdick, Rosio Cabrera, Erin Cobry, Amy Conley Wright, Gabrielle Cook, Joseph P. Daniels, Dominic DiDomenico, Jennifer Eckert, Angelica Ehler, Pamela R. Fain, Rosanna Fiallo‐Scharer, Nicole Frank, Hannah Goettle, Michelle Haarhues, Sherrie Harris, Lauren Horton, John C. Hutton, Joy Jeffrrey, Rachael Jenison, Kelly Jones, Whitney Kastelic, Maria Amelia King, Debbie Lehr, Jenna Lungaro, Kendra Mason, Heather Maurer, Luy Nguyen, Allison Proto, Jaime Realsen, Kristina Schmitt, Mara Schwartz, San Skovgaard, Brandon VanderWel, Mary Voelmle, Rebecca Wagner, Amy E. Wallace, Philip A. Walravens, Laurie Weiner, Becky Westerhoff, Emily Westfall, Katina Widmer, Hali Wright, Annie Abraham, Miriam Cintrón, Jessica Ferguson, Michael J. Haller, Jennifer Hosford, Diane Mancini, Hank Rohrs, Janet Silverstein, Jamie Thomas, Gloria G. Cole, Roberta Cook, Ryan Coy, Elena Hicks, Nancy Davis Lewis, Carlos Blaschke, Natalia Sanders-Branca, Luz Arazo Ray Arce, Mario Cisneros, Samir Sabbag, Carrie Gibson, Brian T. Fife, C. Kwong, Janice Leschyshyn, Brandon M. Nathan, Beth Pappenfus, Anne Street, Mary Boes, Sarah Peterson Eck, Lois Finney, Theresa Fischer, Andrea Martin, Chenai Jacqueline Muzamhindo, Missy Rhodes, John A. Wagner, Bryan Wood, Kelli Delallo, Ana María Díaz, Barbara Elnyczky, Beata Pasek, Karen Riley, Brian Copemen, Diane Gwynn, Frederico G. S. Toledo, Sureka Bollepalli, Frank Diamond, Emily Eyth, Danielle Henson, Anne Lenz, Dorothy I. Shulman, Phillip Raskin, Soumya Adhikari, Brian Dickson, Erin Dunnigan, Ildiko Lingvay, Lourdes Pruneda, María A. Ramos-Román, Chanhaeng Rhee, John Richard, Daytheon Sturges, Kathryn Sumpter, Perrin C. White, Marilyn Alford, Jamie Arthur, Larissa Avilés‐Santa, Erica Cordova, Renee Davis, Stefani Fernandez, Steve Fordan, Tauri Hardin, Aris Jacobs, Polina Kaloyanova, Ivanna Lukacova-Zib, Sasan Mirfakhraee, Alok Mohan, Hiroshi Noto, Oralenda Smith, Nenita Torres, Diana Balmer, Lesley Eisel, Roze Kovalakovska, Mala Mehan, Farah Sultan, Brenda Ahenkorah, José Luis Cevallos, Natasha Razack, Jo Mary Ricci, Angela Rhode, Mithula Srikandarajah, Rachel Steger, William E. Russell, Margo Black, Faith Brendle, Anne Brown, Daniel J. Moore, Eric Pittel, Alyssa Robertson, April Shannon, Laurie Feldman, William V. Tamborlane, Stuart A. Weinzimer, Jorma Toppari, Tiina Kallio, Maarit Kärkkäinen, Elina Mäntymäki, Tiina Niininen, Birgitta Nurmi, Petro Rajala, Minna Romo, Sointu Suomenrinne, Tuula Simell, Manuela Battaglia, Eleonora Bianconi, Riccardo Bonfanti, Pauline Grogan, Andrea Laurenzi, Sabina Martinenghi, Franco Meschi, Matteo Rocco Pastore, Luca Falqui, Maria Teresa Muscato, Matteo Viscardi, Harriet Castleden, Nicola Farthing, Sam Loud, Claire Matthews, Jennifer McGhee, Ann Morgan, Joanna Pollitt, Rebecca Elliot-Jones, Carole Wheaton, Heli Siljander, Heli Suomalainen, Felicity Healy, Shelley Mesfin, Leanne Redl, John M. Wentworth, Jinny Willis, Maree Farley, Leonard C. Harrison, Christine Perry, Fiona Williams

Bibliographic record

VenueThe Journal of Clinical Endocrinology & Metabolism · 2020

Typearticle

Languageen

FieldBiochemistry, Genetics and Molecular Biology

TopicDiabetes and associated disorders

Canadian institutionsWestern UniversityUniversity of Toronto

FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of Allergy and Infectious DiseasesNational Institutes of Health

KeywordsBETA (programming language)Ethnic groupType 2 diabetesDiabetes mellitusBeta cellInternal medicineMedicineChemistryEndocrinologyComputer scienceSociology

DOI10.1210/clinem/dgaa348

Abstract

fetched live from OpenAlex

OBJECTIVE: We set forth to compare ethnicities for metabolic and immunological characteristics at the clinical diagnosis of type 1 diabetes (T1D) and assess the effect of ethnicity on beta-cell functional loss within 3 years after clinical diagnosis. RESEARCH METHODS AND DESIGN: We studied participants in TrialNet New Onset Intervention Trials (n = 624, median age = 14.4 years, 58% male, 8.7% Hispanic) and followed them prospectively for 3 years. Mixed meal tolerance tests (MMTT) were performed within 6 months following clinical diagnosis and repeated semiannually. Unless otherwise indicated, analyses were adjusted for age, sex, BMI Z-score, and diabetes duration. RESULTS: At T1D clinical diagnosis, Hispanics, compared with non-Hispanic whites (NHW), had a higher frequency of diabetic ketoacidosis (DKA) (44.7% vs 25.3%, OR = 2.36, P = 0.01), lower fasting glucose (97 vs 109 mg/dL, P = 0.02) and higher fasting C-peptide (1.23 vs 0.94 ng/mL, P = 0.02) on the first MMTT, and higher frequency of ZnT8 autoantibody positivity (n = 201, 94.1% vs 64%, OR = 7.98, P = 0.05). After exclusion of participants in experimental arms of positive clinical trials, C-peptide area under the curve (AUC) trajectories during the first 3 years after clinical diagnosis were not significantly different between Hispanics and NHW after adjusting for age, sex, BMI-z score, and DKA (n = 413, P = 0.14). CONCLUSION: Despite differences in the metabolic and immunological characteristics at clinical diagnosis of T1D between Hispanics and NHW, C-peptide trajectories did not differ significantly in the first 3 years following clinical diagnosis after adjustment for body mass index and other confounders. These findings may inform the design of observational studies and intervention trials in T1D.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004

metaresearch head score (Gemma)0.010

Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated

Candidate categoriesnone

Consensus categoriesnone

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Observational · Consensus signal: Observational

GenreCandidate signal: Empirical · Consensus signal: Empirical

Teacher disagreement score0.004

Threshold uncertainty score0.021

Distilled classifier scores by category (both heads)

Category	Codex	Gemma
Metaresearch	0.004	0.010
Meta-epidemiology (narrow)	0.000	0.000
Meta-epidemiology (broad)	0.000	0.001
Bibliometrics	0.001	0.001
Science and technology studies	0.000	0.000
Scholarly communication	0.001	0.001
Open science	0.000	0.001
Research integrity	0.001	0.001
Insufficient payload (model declined to judge)	0.002	0.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019

GPT teacher head0.295

Teacher spread0.276 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.

Study designObservational

Domainnot available

GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7

Published2020

Admission routes1

Has abstractyes

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