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Record W3033891518 · doi:10.1530/biosciprocs.10.006

Models of embryonic diapause in Carnivora

2020· article· en· W3033891518 on OpenAlexafffund
B. D. Murphy, Jane C. Fenelon

Bibliographic record

VenueBioscientifica Proceedings · 2020
Typearticle
Languageen
FieldMedicine
TopicReproductive Biology and Fertility
Canadian institutionsUniversité de MontréalOttawa Fertility Centre
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsBiologyDiapausePars tuberalisMinkBlastocystInternal medicineEndocrinologyZoologyEmbryoCell biologyPituitary glandEmbryogenesisEcologyHormone

Abstract

fetched live from OpenAlex

The phenomenon of obligate embryonic diapause, comprising developmental arrest at the blastocyst stage, has been recognized to occur in more than 60 species in three families in the Order Carnivora.The evolutionary advantage believed to be conferred by this trait is that it permits mating and parturition to occur at the most favorable times of year for reproductive success and offspring survival.The carnivore blastocyst in diapause consists of hundreds of cells, configured in the classic mammalian compartments of inner cell mass and trophoblast.It is encapsulated in a glycoprotein coat, derived, at least in part, from the zona pellucida of the parent oocyte.The temporal uncoupling of mating from parturition is regulated by changes in the annual photoperiod, mediated through the pineal gland, pars tuberalis a pars distalis of the pituitary and thyroid glands.In the best-studied species, the pituitary signal that awakes the embryo from arrest is prolactin, acting on the ovary and on the uterus.Ovarian signals, other than progesterone are not well understood, but it appears that there is an ovarian peptide essential for the reactivation of the embryo in mink.New studies have identified the uterine signals in the mink, and it has been shown that the synthesis and secretion of polyamines activates the mink embryo from diapause.While extensive progress has been made, it is not clear whether the regulatory mechanisms that have been identified in the better-known species are universal to carnivore diapause.As many of the carnivore species are endangered, further research on diapause is essential to their survival.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.059
GPT teacher head0.272
Teacher spread0.214 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2020
Admission routes2
Has abstractyes

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