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Record W3035049819 · doi:10.1101/2020.06.15.151217

Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations

2020· preprint· en· W3035049819 on OpenAlexaff
Lifu Deng, Simon W. Davis, Zachary A. Monge, Erik A. Wing, Benjamin R. Geib, Alex Raghunandan, Roberto Cabeza

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2020
Typepreprint
Languageen
FieldNeuroscience
TopicVisual perception and processing mechanisms
Canadian institutionsBaycrest Hospital
FundersNational Institute of Mental HealthNational Institute on AgingNational Institutes of Health
KeywordsMnemonicPsychologyPerceptionSimilarity (geometry)Categorical variableSensory systemCognitive psychologyVisual perceptionNeuroscienceTemporal lobeArtificial intelligenceComputer science

Abstract

fetched live from OpenAlex

Abstract Preliminary evidence indicates that occipito-temporal activation patterns for different visual stimuli are less distinct in older (OAs) than younger (YAs) adults, suggesting a dedifferentiation of visual representations with aging. Yet, it is unclear if this deficit (1) affects only sensory or also categorical aspects of representations during visual perception (perceptual representations), and (2) affects only perceptual or also mnemonic representations. To investigate these issues, we fMRI-scanned YAs and OAs viewing and then remembering visual scenes. First, using representational similarity analyses, we distinguished sensory vs. categorical features of perceptual representations. We found that, compared to YAs, sensory features in early visual cortex were less differentiated in OAs (i.e., age-related dedifferentiation), replicating previous research, whereas categorical features in anterior temporal lobe (ATL) were more differentiated in OAs. This is, to our knowledge, the first report of an age-related hyperdifferentiation . Second, we assessed the quality of mnemonic representations by measuring encoding-retrieval similarity (ERS) in activation patterns. We found that aging impaired mnemonic representations in early visual cortex and hippocampus but enhanced mnemonic representations in ATL. Thus, both perceptual and mnemonic representations in ATL were enhanced by aging. In sum, our findings suggest that aging impairs visual and mnemonic representations in posterior brain regions but enhances them in anterior regions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.045
GPT teacher head0.274
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2020
Admission routes1
Has abstractyes

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