Patch-clamp recordings in slices of telencephalon, diencephalon and rhombencephalon of salamanders
Bibliographic record
Abstract
A bstract The salamander is a key limbed vertebrate from which many major scientific questions can be addressed in the fields of motor control, evolutionary biology, and regeneration biology. An important gap of knowledge is the description of the electrophysiological properties of the neurons constituting their central nervous system. To our knowledge, some patch-clamp electrophysiological recordings were done in the spinal cord and recently in hindbrain slices, but not in any higher brain region. Here, we present a method to obtain patch-clamp recordings in slices of the telencephalon, diencephalon and rhombencephalon of salamanders. The method includes dissection of the brain, brain slice preparation, visual identification of neurons and patch-clamp recordings. We provide single cell recordings in the rhombencephalon, diencephalon and telencephalon of salamanders. This method should open new avenues to dissect the operation of salamander brain circuits at the cellular level. H ighlights - Salamander brain slices of telencephalon, diencephalon, and rhombencephalon - Patch-clamp recordings in salamander brain slices - The salamander as a model to decipher tetrapod neural microcircuits
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".