667 β3-tubulin knockdown interferes with microtubule dynamics, cell-cycle regulation, and microvesicle release in human melanoma cells
Bibliographic record
Abstract
Introduction: Microvesicles (MV), ranging in size from 100 nm to 1000 nm, play an important role in carcinogenesis by promoting angiogenesis and tumor metastasis, interfering with anti-tumor immunity, and inducing multidrug resistance. The release of MVs requires structural changes in microfilaments, intermediate filaments, and microtubules. Class III β-tubulin (β3-tubulin), one of seven β-tubulin isotypes, is a microtubule component involved in malignant transformation and cancer development. Herein, we characterize the effects of β3-tubulin knockdown on microtubule dynamics, cell cycle regulation, and microvesicle formation in human melanoma cells.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".