Domperidone-Related Acute Dystonia in a Young Child With Underlying Abnormal Electroencephalogram
Bibliographic record
Abstract
Domperidone is the preferred treatment for vomiting and gastroesophageal reflux in pediatric population. It is known to have lesser side effects compared to metoclopramide and is rarely associated with extrapyramidal side effects. We report a case of acute dystonia in a 4-year-old girl that occurred after given two doses of domperidone. She initially presented to the emergency department for persistent vomiting and treated with syrup domperidone, ranitidine and oral rehydration salts. Approximately 24 h after last dose of oral domperidone, she developed five episodes of abnormal movement, i.e. stiffness over bilateral upper and lower limbs with eye staring to one direction without blinking. Each episode lasted for less than 10 s and patient did not lose consciousness. No history of head trauma or any family history of neurological diseases was documented. Patient was admitted for workup to rule out seizure. In ward, she developed another two brief episodes of similar presentations which resolved spontaneously without any treatment. No re-occurrence of similar episodes throughout the 3 days of hospitalization was noted. Computed tomography scan of brain confirmed no acute intracranial bleed or focal brain lesion. Electroencephalogram done during subsequent clinic follow-up noted some abnormal records due to increase in slow delta activity, but parents did not consent for magnetic resonance imaging. Patient remained well on biannual follow-up without any seizure or dystonia episode. Rare adverse event involving the central nervous system should be carefully evaluated although product label for domperidone did not mention precaution of use in patients with underlying cerebral abnormalities or epilepsy. Int J Clin Pediatr. 2020;9(2):55-58 doi: https://doi.org/10.14740/ijcp364
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".