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Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

2020· article· en· 706 citations· W3037615636 on OpenAlex· 10.1038/s41591-020-0939-8

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Bench or experimentalNot applicable
Classifier consensus
Bench or experimental
Teacher imitation scores

Codex

Bench or experimental0.937
Other design0.683
Not applicable0.004
Case report0.002
Observational0.001
Open science0.001
Research integrity0.000
Metaresearch0.000
Bibliometrics0.000
Theoretical or conceptual0.000
Qualitative0.000
Meta-analysis0.000
Meta-epidemiology (narrow)0.000
Scholarly communication0.000
Meta-epidemiology (broad)0.000
Randomized trial0.000
Systematic review0.000
Simulation or modelling0.000
Science and technology studies0.000
Non-randomized trial0.000

Gemma

Bench or experimental0.979
Not applicable0.230
Metaresearch0.001
Case report0.001
Observational0.000
Research integrity0.000
Non-randomized trial0.000
Theoretical or conceptual0.000
Open science0.000
Bibliometrics0.000
Meta-epidemiology (narrow)0.000
Randomized trial0.000
Simulation or modelling0.000
Systematic review0.000
Qualitative0.000
Meta-epidemiology (broad)0.000
Science and technology studies0.000
Scholarly communication0.000
Meta-analysis0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.005
GPT teacher head0.246
Teacher spread
0.242 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to joint homeostasis. We used single-cell transcriptomics to profile 32,000 STMs and identified phenotypic changes in patients with early/active RA, treatment-refractory/active RA and RA in sustained remission. Each clinical state was characterized by different frequencies of nine discrete phenotypic clusters…

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