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Record W3040597860 · doi:10.1002/alz.12123

World‐Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

2020· article· en· W3040597860 on OpenAlexafffund
Miia Kivipelto, Francesca Mangialasche, Heather M. Snyder, Ricardo Allegri, Sandrine Andrieu, Hidenori Arai, Laura D. Baker, Sylvie Belleville, Henry Brodaty, Sônia Maria Dozzi Brucki, Ismael Luis Calandri, Paulo Caramelli, Christopher Chen, Howard Chertkow, Effie Chew, Seong Hye Choi, Neerja Chowdhary, Lucía Crivelli, Rafael de la Torre, Yifeng Du, Tarun Dua, Mark A. Espeland, Howard Feldman, Maris Hartmanis, Tobias Hartmann, Megan Heffernan, Christiani Jeyakumar Henry, Chang Hyung Hong, Krister Håkansson, Takeshi Iwatsubo, Jee Hyang Jeong, Gustavo Jimenez‐Maggiora, Edward H. Koo, Lenore J. Launer, Jenni Lehtisalo, Francisco Lopera, Pablo Martínez‐Lage, Ralph N. Martins, Lefkos Middleton, José Luís Molinuevo, Manuel Montero‐Odasso, So Young Moon, Kristal Morales‐Pérez, Ricardo Nitríni, Haakon B. Nygaard, Yoo K. Park, Markku Peltonen, Chengxuan Qiu, Yakeel T. Quiroz, Rema Raman, Naren P. Rao, Vijayalakshmi Ravindranath, Anna Rosenberg, Takashi Sakurai, Rosa María Salinas, Philip Scheltens, Gustavo Sevlever, Hilkka Soininen, Ana Luisa Sosa, Cláudia Kimie Suemoto, Mikel Tainta, Lina Velilla, Yongxiang Wang, Rachel A. Whitmer, Xin Xu, Lisa J. Bain, Alina Solomon, Tiia Ngandu, María C. Carrillo

Bibliographic record

VenueAlzheimer s & Dementia · 2020
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsWestern UniversityUniversity of British ColumbiaUniversity of TorontoBaycrest HospitalUniversité de MontréalInstitut Universitaire de Gériatrie de Montréal
FundersNational Institute on AgingCenter for Innovative MedicineNational Health and Medical Research CouncilMedical Research CouncilCanadian Institutes of Health ResearchNational Institutes of HealthNational Natural Science Foundation of ChinaVetenskapsrådetKnut och Alice Wallenbergs StiftelseJuho Vainion SäätiöKorea Health Industry Development InstituteAlzheimerfondenKarolinska InstitutetSuomen KulttuurirahastoEusko JaurlaritzaSuomen Lääketieteen SäätiöAcademy of FinlandNational University Health SystemConselho Nacional de Desenvolvimento Científico e TecnológicoAlzheimer's AssociationConsortium canadien en neurodégénérescence associée au vieillissementJapan Agency for Medical Research and DevelopmentCHIST-ERAAgence Nationale de la RechercheStichting af Jochnick FoundationAlzheimer SocietySwedish Foundation for International Cooperation in Research and Higher EducationEU Joint Programme – Neurodegenerative Disease ResearchWorld Health Organization
KeywordsDementiaPsychological interventionIntervention (counseling)DiseaseGerontologyMedicineCognitionCognitive declinePsychologyPsychiatry

Abstract

fetched live from OpenAlex

Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.018
metaresearch head score (Gemma)0.023
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.034
Threshold uncertainty score0.113

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0180.023
Meta-epidemiology (narrow)0.0020.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0050.004
Science and technology studies0.0010.001
Scholarly communication0.0040.003
Open science0.0030.009
Research integrity0.0030.003
Insufficient payload (model declined to judge)0.0340.011

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.038
GPT teacher head0.309
Teacher spread0.271 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations521
Published2020
Admission routes2
Has abstractyes

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