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Record W3041665639 · doi:10.1016/j.bpsc.2020.06.019

Dorsolateral Prefrontal Cortex and Subcallosal Cingulate Connectivity Show Preferential Antidepressant Response in Major Depressive Disorder

2020· article· en· W3041665639 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueBiological Psychiatry Cognitive Neuroscience and Neuroimaging · 2020
Typearticle
Languageen
FieldNeuroscience
TopicFunctional Brain Connectivity Studies
Canadian institutionsnot available
FundersJohnson and Johnson Pharmaceutical Research and DevelopmentDivision of Advanced CyberinfrastructureJanssen Research and DevelopmentTakeda Pharmaceuticals InternationalAllerganForest LaboratoriesStony Brook UniversityBausch HealthPatient-Centered Outcomes Research InstituteServierBoehringer IngelheimTaisho Toyama Pharmaceutical CompanyLichtwer PharmaJed FoundationBiogenVistagen TherapeuticsFORUM PharmaceuticalsGlaxoSmithKlineCerecorSage TherapeuticsNational Institute of Mental HealthOrexigen TherapeuticsAmerican Society of Clinical PsychopharmacologyValeant Pharmaceuticals InternationalHersh FoundationJazz PharmaceuticalsVanda PharmaceuticalsCeNeRxH. Lundbeck A/SSunovionOtsuka America PharmaceuticalSchering-PloughNational Center for Complementary and Alternative MedicineSanofiPharmaviteAvanir PharmaceuticalsJohnson and JohnsonTakeda Pharmaceuticals U.S.A.Massachusetts General HospitalNational Institutes of HealthCovidienPfizerACADIA PharmaceuticalsCancer Prevention and Research Institute of TexasEli Lilly and CompanySupernus PharmaceuticalsBristol-Myers SquibbCephalonNovartisJohn Templeton FoundationAmarin PharmaAstraZenecaSolvay PharmaceuticalsAmerican Psychiatric AssociationAbbott LaboratoriesNew York City Department of Health and Mental HygieneBrainCellsNational Institute on Drug AbuseShireImedexNorth Carolina GlaxoSmithKline FoundationBrain and Behavior Research Foundation
KeywordsSertralineDorsolateral prefrontal cortexPsychologyMajor depressive disorderAnterior cingulate cortexAntidepressantPlaceboHamilton Rating Scale for DepressionAmygdalaPrefrontal cortexNeuroscienceClinical psychologyPsychiatryMedicineAnxietyCognition

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.010
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.483
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.010
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0000.001
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.049
GPT teacher head0.285
Teacher spread0.237 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it