Serotonergic Modulation of Sensory Neuron Activity and Behavior in Apteronotus albifrons
Bibliographic record
Abstract
Organisms must constantly adapt to changes in their environment in order to survive. It is thought that neuromodulators such as serotonin enable sensory neurons to better process input encountered during different behavioral contexts. Here, we investigated how serotonergic innervation affects neural and behavioral responses to behaviorally relevant envelope stimuli in the weakly electric fish species Apteronotus albifrons. Under baseline conditions, we found that exogenous serotonin application within the electrosensory lateral line lobe increased sensory neuron excitability, thereby promoting burst firing. We found that serotonin enhanced the responses to envelope stimuli of pyramidal cells within the lateral segment of the electrosensory lateral line lobe (ELL) by increasing sensitivity, with the increase more pronounced for stimuli with higher temporal frequencies (i.e., > 0.2 Hz). Such increases in neural sensitivity were due to increased burst firing. At the organismal level, bilateral serotonin application within the ELL lateral segment enhanced behavioral responses to sensory input through increases in sensitivity. Similar to what was observed for neural responses, increases in behavioral sensitivity were more pronounced for higher (i.e., > 0.2 Hz) temporal frequencies. Surprisingly, comparison between our results and previous ones obtained in the closely related species A. leptorhynchus revealed that, while serotonin application gave rise to similar effects on neural excitability and responses to sensory input, serotonin application also gave rise to marked differences in behavior. Specifically, behavioral responses in A. leptorhynchus were increased primarily for lower (i.e., 0.2 Hz) rather than for higher temporal frequencies. Thus, our results strongly suggest that there are marked differences in how sensory neural responses are processed downstream to give rise to behavior across both species. This is despite the fact that previous results have shown that the behavioral responses of both species to envelope stimuli were identical when serotonin is not applied.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".