Mixing behaviour of Pluronics with gemini surfactant/plasmid DNA condensates: effect of Pluronic composition
Bibliographic record
Abstract
Nanoparticles prepared from plasmid DNA (pDNA) and N,N-bis(dimethylhexadecyl)-1,3-propanediammonium bromide (16-3-16) have been mixed with various Pluronic block copolymers and investigated as binary surfactant systems in water using the previously demonstrated critical aggregation concentration of the surfactant-DNA complex. Surface tensiometry was used to determine critical micelle concentrations of mixed micelles formed within these Pluronic/16-3-16/pDNA mixtures. Use of mixed micelle theories reveals that mixed micelle composition and the interaction parameter, β, are influenced by the structure, in particular hydrophobicity, of the Pluronic component. Ethidium bromide fluorescence studies demonstrate the ability of the Pluronics to de-condense the plasmid DNA from the cationic 16-3-16 gemini surfactant complex, and show some relationship to the interaction parameter and Pluronic composition.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".