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Record W3045069317 · doi:10.3389/fmicb.2020.01661

Past, Present, and Future of Gastrointestinal Microbiota Research in Cats

2020· review· en· W3045069317 on OpenAlexaff
Yang Lyu, Chunxia Su, Adronie Verbrugghe, Tom Van de Wiele, Ana Martos Martinez-Caja, Myriam Hesta

Bibliographic record

VenueFrontiers in Microbiology · 2020
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGut microbiota and health
Canadian institutionsUniversity of Guelph
Fundersnot available
KeywordsFirmicutesBiologyBacteroidetesMicrobiomeProteobacteriaGut floraImmune systemDiseaseActinobacteriaBacterial phylaPopulationHost (biology)MicrobiologyImmunologyBioinformaticsGeneticsBacteriaMedicine

Abstract

fetched live from OpenAlex

The relationship between microbial community and host has profound effects on animal health. A balanced gastrointestinal (GI) microbial population provides nutritional and metabolic benefits to its host, regulates the immune system and various signalling molecules, protects intestines from pathogen invasion and promotes a healthy structure and optimal function of the intestines. With expeditious development of next generation sequencing, molecular techniques have become standard tools for research of microbiota and demonstrated a complex and diverse intestinal ecosystem. Similar to results from other mammals, the vast majority of GI microbiota in cats (over 99%) is composed of the predominant bacterial phyla, Firmicutes, Bacteroidetes, Actinobacteria and Proteobacteria. Many nutritional and clinical studies revealed that several different factors and conditions can alter cats' microbiota, including body condition, age, diet and nutrients, inflammatory disease and others. Further research is warranted to determine functional variations of microbiome in disease states and the response to environmental and dietary modulations, to explain the intricate relationship between GI microbiota and genetics and immunity of its host, and also to improve the existing as well as the future molecular techniques. This review focusing on feline GI microbiota, summarises past and present knowledge and looks into the future prospects.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.751
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.349
Teacher spread0.313 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations49
Published2020
Admission routes1
Has abstractyes

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