Cytotoxicity of New Selenoimine, Selenonitrone and Nitrone Derivatives Against Human Breast Cancer MDA-MB231 Cells
Bibliographic record
Abstract
A series of new nitrone, selenoimine and selenonitrone derivatives were synthesized. Nitrone and selenonitrone derivatives were synthesized through the condensation reaction between N-mono substitutedhydroxylamine and carbonyl compounds substituted with electron donating groups, such as di(4-methoxy)benzoyl diselenide, 4-(N, N-dimethylamino) benzoyl selenonitrile and 4, 4'-di(N, N- dimethylamino)benzil, afforded a variety of new nitrone and selenonitrone compounds. Selenoimine derivative was synthesized through the condensation reaction between tert-butyl amine and (4-methoxybenzoyl selenonitrile). The yield of synthesized compounds (N1, N2, N3, N4 and N5 were (66, 60, 61, 62 and 45) %, respectively. The structures of the synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR, elemental analysis and Mass spectroscopy. Cytotoxicity of selenonitrone (N1) and selenoimine (N3) derivatives against breast cancer cells (MDA-MB231) were evaluated for 24 and 48 h via MTT assay. The IC50 value of compound N1 were 1.714 and 1.897 µM for 24 h and 48 h, respectively. The IC50 values of compound N3 were 1.438 and 2.469 µM for 24 h and 48 h, respectively. The results suggested selenonitrone (N1) and selenoimine (N3) as anti-breast cancer potential lead compound with future merit investigations.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".