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Record W3045528856 · doi:10.3389/fonc.2020.01107

Optimizing MR-Guided Radiotherapy for Breast Cancer Patients

2020· review· en· W3045528856 on OpenAlexaff
M. Groot Koerkamp, Jeanine E. Vasmel, Nicola S. Russell, Simona F. Shaitelman, Carmel Anandadas, Adam Currey, Danny Vesprini, Brian Keller, Chiara De‐Colle, Kathy Han, Lior Z. Braunstein, Faisal Mahmood, Ebbe Laugaard Lorenzen, M.E.P. Philippens, Helena M. Verkooijen, J J W Lagendijk, Antonetta C. Houweling, H.J.G.D. van den Bongard, Anna M. Kirby

Bibliographic record

VenueFrontiers in Oncology · 2020
Typereview
Languageen
FieldPhysics and Astronomy
TopicAdvanced Radiotherapy Techniques
Canadian institutionsPrincess Margaret Cancer CentreUniversity of TorontoSunnybrook Health Science CentreUniversity Health NetworkHealth Sciences Centre
FundersNational Cancer InstituteCancer Research UK
KeywordsMedicineRadiation therapyBreast cancerCancerMedical physicsOncologyRadiologyInternal medicine

Abstract

fetched live from OpenAlex

Current research in radiotherapy for breast cancer is evaluating neoadjuvant as opposed to adjuvant partial breast irradiation with the aim of reducing the volume of breast tissue irradiated and therefore the risk of late treatment-related toxicity. The development of MR-guided radiotherapy, including dedicated MR-guided radiotherapy systems (hybrid machines combining an MR-scanner with a linear accelerator (MR-linac) or 60 Co sources) could potentially reduce the irradiated volume even further by improving tumour visibility before and during each radiotherapy treatment. In this position paper we discuss MR-guidance in relation to each step of the breast radiotherapy planning and treatment pathway, focussing on the application of MR-guided radiotherapy to neoadjuvant partial breast irradiation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.953
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.371
Teacher spread0.347 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations58
Published2020
Admission routes1
Has abstractyes

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