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Record W3045815733 · doi:10.1080/22221751.2020.1796528

Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus

2020· article· en· W3045815733 on OpenAlexfundno aff
Anges Yadouléton, Caroline Picard, Toni Rieger, Frédéric Loko, Dániel Cadar, Emile Cossi Kouthon, Emmanuel Obolli Job, Honoré Bankole, Lisa Oestereich, Fernand Gbaguidi, Meike Pahlman, Beate Becker‐Ziaja, Alexandra Journeaux, Delphine Pannetier, Stéphane Mély, Stéphanie Mundweiler, Damien Thomas, Leon Kohossi, Raoul Saizonou, Magloire Da Silva, Sonia Kossoubedie, André Lukusa Kakonku, Pierre MʼPelé, Stephan Günther, Sylvain Baize, Élisabeth Fichet-Calvet

Bibliographic record

VenueEmerging Microbes & Infections · 2020
Typearticle
Languageen
FieldMedicine
TopicViral Infections and Outbreaks Research
Canadian institutionsnot available
FundersHorizon 2020Bundesministerium für GesundheitAgence Nationale de la RechercheEuropean CommissionInstitut National de la Santé et de la Recherche MédicaleDeutsche ForschungsgemeinschaftInstitute of Population and Public HealthWorld Health Organization
KeywordsLassa feverLassa virusVirologySierra leoneTransmission (telecommunications)BiologyOutbreakPandemicGenetic diversityStrain (injury)Lineage (genetic)VirusDiseaseMedicineCoronavirus disease 2019 (COVID-19)GeneticsSocioeconomicsPopulationEnvironmental healthInfectious disease (medical specialty)Gene

Abstract

fetched live from OpenAlex

We report two outbreaks of Lassa fever that occurred in Benin in 2014 and 2016 with 20 confirmed cases and 50% (10/20) mortality. Benin was not previously considered to be an endemic country for Lassa fever, resulting in a delay to diagnose the disease and its human transmission. Molecular investigations showed the viral genomes to be similar to that of the Togo strain, which is genetically very different from other known strains and confirms the existence of a new lineage. Endemic circulation of Lassa virus in a new territory and the genetic diversity thus confirm that this virus represents a growing threat for West African people. Given the divergence of the Benin strain from the prototypic Josiah Sierra Leone strain frequently used to generate vaccine candidates, the efficacy of vaccine candidates should also be demonstrated with this strain.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.276
Teacher spread0.249 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations51
Published2020
Admission routes1
Has abstractyes

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