Cross Entropy Based Sparse Logistic Regression to Identify Phenotype-Related Mutations in Methicillin-Resistant <i>Staphylococcus aureus</i>
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Emergence of drug resistant bacteria is one of the serious problems in today’s public health. However, the relationship between genomic mutation of bacteria and the phenotypic difference of them is still unclear. In this paper, based on the mutation information in whole genome sequences of 96 MRSA strains, two kinds of phenotypes (pathogenicity and drug resistance) were learnt and predicted by machine learning algorithms. As a result of effective feature selection by cross entropy based sparse logistic regression, these phenotypes could be predicted in sufficiently high accuracy (100% and 97.87%, respectively) with less than 10 features. It means that we could develop a novel rapid test method in the future for checking MRSA phenotypes.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it