Structural Biology 2019: Nrf2, the key transcription factor that regulates the cellular response to oxidative stress, is intrinsically disordered- Nadun Chanaka Karunatilleke- The University of Western Ontario
Bibliographic record
Abstract
Receptive oxygen and nitrogen species (ROS, RNS) are continually produced in the body from interior digestion and outside introduction. In ordinary cells, responsive oxidants are created in a controlled way and some fill helpful needs. Oxidants shaped in light of physiological prompts go about as significant flagging particles to direct such procedures as cell division, aggravation, insusceptible capacity, autophagy, and stress reaction. Uncontrolled creation of oxidants brings about oxidative pressure that impedes cell capacities and adds to the improvement of malignancy, incessant illness, and poisonousness (2–5). From prokaryotes to people, responsive oxidants apparently work as significant controllers of both physiological and pathophysiological results.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".