Sulfamethoxazole-Trimethoprim and Hyperkalemia in an Infant
Bibliographic record
Abstract
Hyperkalemia is a potentially life-threatening electrolyte abnormality in both children and adults. In the setting of elevated serum potassium concentrations, cardiac conduction disturbances and cardiac arrest may occur. In the pediatric intensive care unit (PICU) setting, the differential diagnosis of hyperkalemia may be extensive including increased potassium intake or administration, increased endogenous production, decreased renal excretion, and intracellular to extracellular shifts related to changes in acid-base status. We present a 4-month-old infant who developed hyperkalemia during the recovery phase of her PICU course for respiratory failure. A thorough investigation demonstrated that the hyperkalemia was most likely the result of the commonly used antibiotic, trimethoprim-sulfamethoxazole (Bactrim ® ). Potential etiologies of hyperkalemia in the PICU patient are discussed and previous reports of hyperkalemia associated with trimethoprim-sulfamethoxazole presented. J Med Cases. 2020;11(9):283-285 doi: https://doi.org/10.14740/jmc3498
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".