Bibliographic record
Abstract
Gene therapies for systemic diseases such as cancer or inflammatory disorders clearly require systemic vectors. Previous work has shown that encapsulation of chemotherapeutic drugs in small, long-circulating liposomes results in preferential accumulation at tumour sites. It follows that encapsulation of plasmid in small liposomal systems should result in enhanced delivery of plasmid to tumour sites. We have developed a method for encapsulating plasmid in small (diameter~70nm) "stabilized plasmid-lipid particles " (SPLP) employing a detergent dialysis procedure [1]. These SPLP contain one plasmid per particle and are stabilized in aqueous media by the presence of a poly(ethyleneglycol) (PEG) coating. SPLP are non-toxic, exhibit extended circulation lifetimes following intravenous injection and result in delivery of up to 3 % of the injected dose to a distal tumour site [2,3]. It is shown that SPLP exhibit remarkable selectivity for transfection of tumour tissue as compared to organs such as the lung, liver or spleen. Initial studies utilizing SPLP for suicide gene therapy applications employing thymidine kinase gene delivery in
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".