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Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers

2020· article· en· W3080415720 on OpenAlexafffund
Antonio R. Cerullo, Tsoi Ying Lai, Bassem Allam, Alexander B. Baer, W. Jon. P. Barnes, Zaidett Barrientos, Dimitri D. Deheyn, Douglas S. Fudge, John Gould, Matthew J. Harrington, Mandë Holford, Chia‐Suei Hung, Gaurav Jain, Georg Mayer, Mónica Medina, Julían Mónge-Nájera, Tanya Napolitano, Emmanuelle Pales Espinosa, Stephan Schmidt, Eric M. Thompson, Adam B. Braunschweig

Bibliographic record

VenueACS Biomaterials Science & Engineering · 2020
Typearticle
Languageen
FieldMaterials Science
TopicSilk-based biomaterials and applications
Canadian institutionsMcGill University
FundersAir Force Office of Scientific ResearchNational Institute on Minority Health and Health DisparitiesDivision of Integrative Organismal SystemsNatural Sciences and Engineering Research Council of CanadaNorges ForskningsrådDeutsche ForschungsgemeinschaftVicerrectoría de Investigación, Universidad de Costa RicaWellcomeRoyal SocietyCity University of New YorkDivision of Ocean SciencesWellcome TrustCamille and Henry Dreyfus Foundation
KeywordsMucusFunction (biology)Structure functionNanotechnologyBiologyComputational biologyComputer scienceEvolutionary biologyEcologyMaterials sciencePhysics

Abstract

fetched live from OpenAlex

The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the hierarchical architectures, material properties, and genetics of mucus remain. Here, we summarize what is known about secreted mucus structure, describe the work of research groups throughout the world who are investigating various animal mucuses, and relate how these studies are revealing new mucus properties and the relationships between mucus hierarchical structure and hydrogel function. Finally, we call for a more systematic approach to studying animal mucuses so that data sets can be compared, omics-style, to address unanswered questions in the emerging field of mucomics. One major result that we anticipate from these efforts is design rules for creating new materials that are inspired by the structures and functions of animal mucuses.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.002
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.002
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.051
GPT teacher head0.264
Teacher spread0.213 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations30
Published2020
Admission routes2
Has abstractyes

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