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Pediatric Neurology Research in the Twenty-First Century: Status, Challenges, and Future Directions Post–COVID-19

2020· article· en· W3080449855 on OpenAlexaff
Joshua L. Bonkowsky, Gabrielle deVeber, Barry E. Kosofsky, Erika F. Augustine, Alexander G. Bassuk, Amy R. Brooks‐Kayal, Ryan J. Felling, Heather J. Fullerton, Hannah C. Glass, Zachary M. Grinspan, Réjean M. Guerriero, Michael Johnston, Ariel M. Lyons‐Warren, Steven Maricich, Patricia L. Musolino, Scott L. Pomeroy, Brenda E. Porter, Jong M. Rho, Alexander Rotenberg, Bradley L. Schlaggar, Renée A. Shellhaas, Elliott H. Sherr, Janet S. Soul

Bibliographic record

VenuePediatric Neurology · 2020
Typearticle
Languageen
FieldHealth Professions
TopicAdolescent and Pediatric Healthcare
Canadian institutionsSickKids FoundationHospital for Sick ChildrenUniversity of Toronto
FundersNational Institute of Neurological Disorders and StrokeNational Cancer InstituteNational Institute of Mental HealthWeill Cornell Medical CollegeNational Institutes of HealthEpilepsiatutkimussäätiöbluebird bioPTC TherapeuticsBrainsWayAbeona TherapeuticsEisaiJazz PharmaceuticalsPatient-Centered Outcomes Research InstituteWashington University in St. LouisDenali TherapeuticsPediatric Epilepsy Research FoundationChild Neurology FoundationNational Center for Advancing Translational SciencesBeyond Batten Disease FoundationBiogenBatten Disease Support and Research Association
KeywordsNeurologyPandemicMedicineInclusion (mineral)Pediatric NeurologyClinical trialHealth careHealth equityWorkforcePublic healthFamily medicineDiseasePsychologyPolitical scienceCoronavirus disease 2019 (COVID-19)PediatricsNursingPsychiatryInfectious disease (medical specialty)

Abstract

fetched live from OpenAlex

BACKGROUND: The year 2020 marked a fundamental shift in the pediatric neurology field. An impressive positive trajectory of advances in patient care and research faced sudden global disruptions by the coronavirus disease 2019 pandemic and by an international movement protesting racial, socioeconomic, and health disparities. The disruptions revealed obstacles and fragility within the pediatric neurology research mission. However, renewed commitment offers unique opportunities for the pediatric neurology research community to enhance and prioritize research directions for the coming decades. METHODS: The Research Committee of the Child Neurology Society evaluated the challenges and opportunities facing the pediatric neurology research field, including reviewing published literature, synthesizing publically available data, and conducting a survey of pediatric neurologists. RESULTS: We identified three priority domains for the research mission: funding levels, active guidance, and reducing disparities. Funding levels: to increase funding to match the burden of pediatric neurological disease; to tailor funding mechanisms and strategies to support clinical trial efforts unique to pediatric neurology; and to support investigators across their career trajectory. Active guidance: to optimize infrastructure and strategies, to leverage novel therapeutics, enhance data collection, and improve inclusion of children in clinical trials. Reducing disparities: to reduce health disparities in children with neurological disease, to develop proactive measures to enhance workforce diversity and inclusion, and increase avenues to balance work-life obligations for investigators. CONCLUSIONS: In this uniquely challenging epoch, the pediatric neurology research community has a timely and important mission to re-engage the public and government, advancing the health of children with neurological conditions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Science and technology studies, Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.604
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.002
Science and technology studies0.0020.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0010.006
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.153
GPT teacher head0.429
Teacher spread0.275 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations11
Published2020
Admission routes1
Has abstractyes

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