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Cancer and Risk of COVID-19 Through a General Community Survey

2020· article· en· W3080782372 on OpenAlexfundno aff
Karla A. Lee, Wenjie Ma, Daniel Sikavi, David A. Drew, Long H. Nguyen, Ruth C. E. Bowyer, M. Jorge Cardoso, Tove Fall, Maxim B. Freidin, Maria F. Gomez, Mark S. Graham, Chuan‐Guo Guo, Amit D. Joshi, Sohee Kwon, Chun‐Han Lo, Mary Ní Lochlainn, Cristina Menni, Benjamin Murray, Raaj S. Mehta, Mingyang Song, Carole H. Sudre, Véronique Bataille, Thomas Varsavsky, Alessia Visconti, Paul W. Franks, Jonathan Wolf, Claire J. Steves, Sébastien Ourselin, Tim D. Spector, Andrew T. Chan

Bibliographic record

VenueThe Oncologist · 2020
Typearticle
Languageen
FieldMedicine
TopicCOVID-19 and healthcare impacts
Canadian institutionsnot available
FundersEngineering and Physical Sciences Research CouncilMedical Research CouncilStand Up To CancerStiftelsen för Strategisk ForskningNational Institute for Health and Care ResearchMedical Research Council CanadaMassachusetts Consortium on Pathogen ReadinessWellcome TrustAlzheimer's SocietyKing's College LondonSeerave FoundationCrohn's and Colitis FoundationBritish Heart Foundation
KeywordsCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CancerPandemicMedicineGeographyVirologyPathologyDiseaseInternal medicineOutbreakInfectious disease (medical specialty)

Abstract

fetched live from OpenAlex

Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.050
Threshold uncertainty score0.100

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.002
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.350
GPT teacher head0.494
Teacher spread0.144 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations78
Published2020
Admission routes1
Has abstractyes

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