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Cancer and Risk of COVID-19 Through a General Community Survey

2020· article· en· W3080782372 on OpenAlex
Karla A. Lee, Wenjie Ma, Daniel Sikavi, David A. Drew, Long H. Nguyen, Ruth C. E. Bowyer, M. Jorge Cardoso, Tove Fall, Maxim B. Freidin, Maria F. Gomez, Mark S. Graham, Chuan‐Guo Guo, Amit D. Joshi, Sohee Kwon, Chun‐Han Lo, Mary Ní Lochlainn, Cristina Menni, Benjamin Murray, Raaj S. Mehta, Mingyang Song, Carole H. Sudre, Véronique Bataille, Thomas Varsavsky, Alessia Visconti, Paul W. Franks, Jonathan Wolf, Claire J. Steves, Sébastien Ourselin, Tim D. Spector, Andrew T. Chan

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueThe Oncologist · 2020
Typearticle
Languageen
FieldMedicine
TopicCOVID-19 and healthcare impacts
Canadian institutionsnot available
FundersEngineering and Physical Sciences Research CouncilMedical Research CouncilStand Up To CancerStiftelsen för Strategisk ForskningNational Institute for Health and Care ResearchMedical Research Council CanadaMassachusetts Consortium on Pathogen ReadinessWellcome TrustAlzheimer's SocietyKing's College LondonSeerave FoundationCrohn's and Colitis FoundationBritish Heart Foundation
KeywordsCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CancerPandemicMedicineGeographyVirologyPathologyDiseaseInternal medicineOutbreakInfectious disease (medical specialty)

Abstract

fetched live from OpenAlex

Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.274
Threshold uncertainty score0.967

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.350
GPT teacher head0.494
Teacher spread0.144 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it