Could Infections with Parasites Prevent Autoimmune Diseases, Like Asthma and Crohn's Disease?
Bibliographic record
Abstract
Increasing rates of autoimmune diseases, such as asthma and Crohn’s disease, have become a major concern in industrialized countries. One potential cause for the rising rates of autoimmune diseases in humans, is the disconnected relationship to parasites due to better hygiene. The extensive history between parasites and humans has resulted in the evolution of immunomodulating characteristics in parasites that may prevent the development of autoimmune diseases in humans. Here, I discuss the evolutionary reason for the protective effect against autoimmune diseases provided by parasites, explain the hygiene hypothesis as it relates to parasites, and propose the immunological mechanisms of parasites that might confer protection from autoimmune diseases. I will also give evidence for the protective effect and indicate the current state of helminth therapy and its challenges. While helminth therapy may be an effective treatment and prevention method for autoimmune diseases, much more research needs to be conducted in order to determine the specific mechanisms of action on our immune systems, and how these could be used medically to treat autoimmune diseases.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".