Long-Term Effect of Dupilumab With Concomitant Topical Corticosteroids on POEM in Adults With Moderate-to-Severe Atopic Dermatitis: LIBERTY AD CHRONOS Trial
Bibliographic record
Abstract
BACKGROUND• The Patient-Oriented Eczema Measure (POEM) is a validated, 7-item questionnaire, which assesses patient-reported frequency of atopic dermatitis (AD) symptoms from the previous week 1-3 -The Harmonising Outcome Measures for Eczema initiative recommends POEM as the core outcome instrument for measuring patient-reported AD symptoms in clinical trials 4 • Dupilumab is a fully human monoclonal antibody 5,6 that blocks the shared receptor component for interleukin (IL)-4 and IL-13, thus inhibiting signaling of both IL-4 and IL-13, which are key and central drivers of type 2 infl ammation in multiple diseases 7 • In the 52-week, phase 3, randomized, double-blinded LIBERTY AD CHRONOS trial (NCT02260986), dupilumab with concomitant topical corticosteroids (TCS) vs placebo with TCS signifi cantly improved AD signs, symptoms, and patient quality of life with an acceptable safety profi le 8 Long-Term Effect of Dupilumab With Concomitant Topical Corticosteroids on POEM in Adults With Moderate-to-Severe Atopic
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".