Metástasis: un hito para el conocimiento, un reto para la ciencia
Bibliographic record
Abstract
RESUMEN Introducción: La metástasis del cáncer es la transferencia de células tumorales de un órgano a otro mediante una serie de multipasos secuenciales interrelacionados. Este proceso es uno de los principales retos en el tratamiento del cáncer debido a su heterogeneidad biológica. El proceso de metástasis es considerado la principal causa de muerte en esta enfermedad, reportándose que más de 90 % de las muertes por cáncer son debidos a esta etapa. Objetivo: Actualizar los conocimientos sobre metástasis en tumores sólidos y su asociación con transición epitelial-mesenquimal (EMT) en relación a la evolución y emergencia del cáncer. Método: Se realizó una revisión, no sistemática, de los estudios más significativos sobre el tema, publicados en la Web of Science, Pubmed, Ebsco, Scopus e Infomed. Conclusiones: La metástasis es la principal causa de muerte del cáncer, por lo que entender las bases del mecanismo de la formación de tumores metastásicos permitirá realizar terapias más eficaces para tratar el cáncer.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.008 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.005 | 0.005 |
| Science and technology studies | 0.002 | 0.009 |
| Scholarly communication | 0.012 | 0.010 |
| Open science | 0.001 | 0.004 |
| Research integrity | 0.003 | 0.005 |
| Insufficient payload (model declined to judge) | 0.018 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".