Xenobiotic Induced Expression of Epsilon Glutathione S – Transferases Gste2 In Laboratory Strains of Anopheles Arabiensis
Why this work is in the frame
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Bibliographic record
Abstract
Over expression of GSTe2 has been associated with resistance to DDT in An . arabiensis. The expression of the gene was induced by exposing the fourth instar larvae obtained from KGB and MAT strains to xenobiotic inducers. Transcripts levels of GSTe2 in cDNAs of the larvae from each strain was measured by quantitative PCR at various time points post exposure to DDT, permethrin and hydrogen peroxide. Statistical analysis was used to test for differences and compare the expression of the gene between treatments and mosquito strains. The geometric mean expression levels of GSTe2 induced at one hour by DDT in the KGB was 1.028 (CI 0.901~1.172; p < 100) compared to 0.587 (CI 0.475~0.724; p = 0.025) in MAT strain. Higher induction of GSTe2 in KGB was caused by DDT and hydrogen peroxide and with permethrin and DDT in MAT strain. Further research is needed to understand the molecular mechanisms regulating response of An. arabiensis to xenobitics.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it