Inflammation and intussusceptive angiogenesis in COVID-19: everything in and out of flow
Bibliographic record
Abstract
We recently showed that SARS-CoV-2 infection leads to angiocentric inflammation in COVID-19-induced respiratory failure, with a greater number of ACE2-positive endothelial cells compared to uninfected controls or to post mortem lung tissue from patients who succumbed to influenza A-related acute respiratory distress syndrome (ARDS) [1]. Although the detection of SARS-CoV-2 in post mortem tissue by transmission electron microscopy is a challenging task [4], replicated virus-like particles were observed enveloped in endothelial cells [1, 5] and lymphatic cells [6], and also in type 2 and 1 pneumocytes [6, 7]. Increasing clinical evidence shows that endothelial dysfunction is a common denominator after SARS-CoV-2 infection in the multi-organ complexity and severity of COVID-19 [3]. Inflammation and intussusceptive angiogenesis in COVID-19 <https://bit.ly/30lLh8K>
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.034 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".