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Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib

2020· article· en· 1,212 citations· W3090413519 on OpenAlex· 10.1001/jamaoncol.2020.4564

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Randomized trialNon-randomized trialObservationalCase reportNot applicable
Classifier consensus
Randomized trialObservational
Teacher imitation scores

Codex

Randomized trial0.518
Observational0.263
Other design0.030
Case report0.030
Not applicable0.009
Qualitative0.001
Non-randomized trial0.000
Bench or experimental0.000
Open science0.000
Research integrity0.000
Simulation or modelling0.000
Meta-analysis0.000
Metaresearch0.000
Bibliometrics0.000
Systematic review0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Science and technology studies0.000
Scholarly communication0.000
Theoretical or conceptual0.000

Gemma

Randomized trial0.522
Observational0.155
Not applicable0.047
Simulation or modelling0.014
Non-randomized trial0.004
Bench or experimental0.000
Systematic review0.000
Qualitative0.000
Meta-analysis0.000
Case report0.000
Research integrity0.000
Metaresearch0.000
Open science0.000
Meta-epidemiology (narrow)0.000
Bibliometrics0.000
Scholarly communication0.000
Science and technology studies0.000
Meta-epidemiology (broad)0.000
Theoretical or conceptual0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.024
GPT teacher head0.232
Teacher spread
0.208 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

IMPORTANCE

Most patients with hepatocellular carcinoma (HCC) are diagnosed with advanced disease not eligible for potentially curative therapies; therefore, new treatment options are needed. Combining nivolumab with ipilimumab may improve clinical outcomes compared with nivolumab monotherapy.

OBJECTIVE

To assess efficacy and safety of nivolumab plus ipilimumab in patients with advanced HCC who were previously treated with sorafenib. DESIGN, SETTING, AND PARTICIPANTS: CheckMate 040 is a multicenter, open-label, multic…

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