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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

2010· article· en· 1,636 citations· W3093265161 on OpenAlex· 10.1016/s0140-6736(10)60892-6

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
The Lancet
Topic
PARP inhibition in cancer therapy
Field
Medicine
Canadian institutions
Funders
Susan G. KomenCancer Research SocietyAstraZeneca
Keywords
OlaparibMedicineTolerabilityBreast cancerCohortPARP inhibitorInternal medicineBRCA mutationOncologyAdverse effectNauseaCancerPoly ADP ribose polymerasePolymeraseBiologyGenetics
Has abstract in OpenAlex
no