Design and synthesis of a lactam bridge stabilized coiled-coil template for library display
Bibliographic record
Abstract
Peptide libraries made up of millions of randomized peptide sequences have proven useful for the identification of novel ligands that maybe of interest for the development of medicinally active compounds [1, 2]. However, simple linear peptides libraries possess considerable conformational flexibility and can populate multiple random-like conformations. An alternative to linear peptide libraries is to incorporate randomized positions in stable secondary structural elements. To this end we envisaged utilizing the well characterized secondary structural element, the two-stranded α-helical coiled-coil as a template for peptide library development. The coiled-coil structure consists of two amphipathic helices wrapped around each other with a left-handed super twist. The coiled-coil is characterized by a heptad repeat denoted (abcdefg )n where positions a and d are typically occupied by hydrophobic amino acids (Figure 1). Design and synthesis of a lactam bridge stabilized coiled-coil template for library display
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".