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Immunometabolic Interplay in the Tumor Microenvironment

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Not applicable
Classifier consensus
N/A
Teacher imitation scores

Codex

Other design0.963
Systematic review0.004
Not applicable0.004
Meta-analysis0.003
Bench or experimental0.001
Research integrity0.000
Meta-epidemiology (broad)0.000
Bibliometrics0.000
Meta-epidemiology (narrow)0.000
Open science0.000
Observational0.000
Non-randomized trial0.000
Case report0.000
Metaresearch0.000
Qualitative0.000
Simulation or modelling0.000
Science and technology studies0.000
Scholarly communication0.000
Randomized trial0.000
Theoretical or conceptual0.000

Gemma

Not applicable0.999
Systematic review0.022
Bench or experimental0.002
Meta-analysis0.001
Research integrity0.000
Bibliometrics0.000
Meta-epidemiology (broad)0.000
Metaresearch0.000
Meta-epidemiology (narrow)0.000
Open science0.000
Observational0.000
Qualitative0.000
Case report0.000
Science and technology studies0.000
Scholarly communication0.000
Randomized trial0.000
Non-randomized trial0.000
Simulation or modelling0.000
Theoretical or conceptual0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.021
GPT teacher head0.299
Teacher spread
0.278 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Immune cells' metabolism influences their differentiation and function. Given that a complex interplay of environmental factors within the tumor microenvironment (TME) can have a profound impact on the metabolic activities of immune, stromal, and tumor cell types, there is emerging interest to advance understanding of these diverse metabolic phenotypes in the TME. Here, we discuss cell-extrinsic contributions to the metabolic activities of immune cells. Then, considering recent technical advances in experimental systems and metabolic profiling technologies, we propose future directions to better understand how immune cells meet their metabolic demands in the TME, which can be leveraged for therapeutic benefit.

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